The heatmap below shows the availability scores we assigned to denote how completely a certain data modality is available and shared in the investigated cohort datasets. The corresponding criteria for score assignments are shown in the table below the heatmap.
The following table illustrates the criteria used to define the availability scores for each investigated data modality. Following clear curation criteria helps to make the scores more comparable and interpretable.
| Score | Clinical | MRI | Demographics | Blood Transcriptomics | Genotype | Blood Proteomics | CSF | PET | Lifestyle | Family | Comorbidities | Autopsy | Medication | Digital Biomarkers | Immunophenotyping |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | Not performed | Not performed | Not available | Not performed | Not performed | Not performed | Not performed | Not performed | Not available | Not available | Not available | Not performed | Not available | Not performed | Not performed |
| 1 | 1-4 assessments ( Diagnosis not counted) | Only processed data | Sex, Age | Only processed data | APOE | Only processed data | At least 1 of: A-beta, pTau, tTau | At least 1 of: FDG PET, Amyloid PET, AV PET | At least 1 of: Substance consumption; physical activity; nutrition | Dementia state of biological parents | Information on at least 1 comorbidity | Basic information (e.g. brain weight) | AD medication | At least 1 digital endpoint | Only processed data |
| 2 | 5 =< assessments | Raw MRI images | Sex, Age, Education, Race/Ethnicity | Raw data | Broad genotyping | Raw data | A-beta, pTau, tTau | FDG PET, PiB PET, AV PET | At least information on 2 of the above | Additional Information | Information on 5 =< other diseases | Omics data or antibody assays conducted | Detailed medication | 2 or more digital endpoints | Raw data |