Cohorts

Explore individual feature distributions

Enter your variable of interest and select the cohorts to be compared against each other. Click here for a list of all the variables available for comparison and their synonyms. For a list of modality specific variables use the buttons below.

Assessment frequency of variables across cohorts

The plots below describe how often a specific variable was encountered in the investigated cohort datasets. Zoom into the plot to explore it in detail and see all variables on the y-axis. To evaluate in which cohorts one specific variable was available, please use the StudyPicker or comparison tool above.

CLINICAL 34 Variables

DEMOGRAPHICS 20 Variables

APOE 4 Variables

COMORBIDITIES 23 Variables

LIFESTYLE 7 Variables

FAMILY 9 Variables

CSF 15 Variables

PLASMA 9 Variables

MRI 1049 Variables

PET 24 Variables

Summary Statistics of Demographic Variables and Selected Biomarkers

The table below summarizes the demographic characteristics of each cohort and describes the distributions of some important Alzheimer’s disease biomarkers at each study's baseline. Distributions of demographic and biomarker values are described using the 25, 50 and 75% quantiles of the absolute measured values. To make biomarker measures more comparable across cohorts, we additionally report the deviation from the healthy control group of one respective cohort and a selected participant subgroup of the same study (i.e. all, healthy, MCI and AD). This deviation is given as the quantiles received when evaluating the absolute quantiles under the empirical cumulative distribution function (ECDF) of the control group of the respective cohort.

Legend

	Female %	Age	Education	APOE4 %	MMSE	CDR	CDRSB	Hippocampus	A-beta	tTau	pTau
A4	57.7	68, 71, 75	14, 16, 18	34.3	28, 29, 30	0.0, 0.0, 0.0	0.0, 0.0, 0.0	6, 7, 7 (25, 50, 75)
ABVIB	42.9	73, 77, 82	14, 16, 18
ADNI	47.0	68, 73, 78	14, 16, 18	45.6	26, 28, 29	0.0, 0.5, 0.5	0.0, 1.0, 2.0	5948, 6864, 7651 (7, 26, 60)	596, 854, 1396 (12, 27, 57)	193, 258, 350 (36, 66, 88)	17, 24, 34 (37, 69, 91)
AIBL	57.9	67, 73, 79	10, 12, 15	36.0	26, 28, 30	0.0, 0.0, 0.5	0.0, 0.0, 1.0	3, 3, 3 (11, 37, 71)	445, 567, 802 (nan)	238, 366, 516 (nan)	43, 64, 81 (nan)
ANM	59.3	71, 77, 81	8, 11, 14	38.8	24, 28, 29	0.0, 0.5, 0.5	0.0, 0.5, 4.0	5311, 6270, 7142 (2, 20, 54)
ARWIBO	60.8	48, 64, 74	5, 8, 13	29.3	24, 28, 29	0.0, 0.0, 0.5		6242, 7415, 8266 (5, 30, 63)	331, 445, 667 (0, 0, 100)	232, 367, 602 (0, 0, 100)	45, 65, 93 (0, 0, 0)
DOD-ADNI	0.9	66, 68, 72	13, 15, 17	26.6	27, 29, 30	0.0, 0.0, 0.5	0.0, 0.0, 0.5	7145, 7777, 8498 (24, 50, 75)	797, 1225, 1512 (27, 51, 78)	154, 198, 254 (26, 52, 78)	13, 17, 22 (26, 53, 78)
EDSD	52.1	67, 71, 76	10, 12, 14	47.0	24, 27, 29			5937, 6833, 7807 (2, 17, 55)	414, 534, 852 (nan)	241, 386, 609 (nan)	51, 72, 102 (nan)
EMIF	45.9	62, 68, 74	9, 12, 15		25, 28, 29	0.5, 0.5, 0.5		6338, 7201, 7981 (5, 26, 63)	383, 522, 732 (10, 37, 66)	160, 280, 506 (37, 74, 95)	37, 52, 74 (39, 71, 93)
EPAD	56.1	60, 66, 71	12, 15, 17	39.4	28, 29, 30	0.0, 0.0, 0.5	0.0, 0.0, 0.5	4375, 4781, 5169 (25, 50, 75)	858, 1273, 1700 (25, 50, 100)	163, 202, 263 (25, 50, 75)	13, 17, 23 (25, 50, 75)
I-ADNI	58.4	65, 73, 77	5, 7, 13		18, 22, 26	0.5, 1.0, 1.0		4997, 5841, 6866
JADNI	52.7	66, 72, 77	12, 12, 16	46.1	24, 26, 29	0.0, 0.5, 0.5	0.0, 1.5, 3.0	5262, 6134, 7126 (1, 7, 40)	254, 315, 454 (7, 13, 46)	67, 101, 138 (59, 89, 96)	36, 48, 73 (59, 89, 96)
NACC	57.1	65, 72, 79	12, 16, 18	40.7	23, 27, 29	0.0, 0.5, 0.5	0.0, 1.0, 4.0	6, 6, 7 (11, 37, 67)	302, 504, 758 (12, 33, 64)	126, 270, 491 (21, 55, 85)	30, 44, 69 (30, 62, 87)
OASIS	60.8	30, 69, 78	3, 5, 12		26, 29, 30	0.0, 0.0, 0.5		5899, 6944, 7843 (11, 34, 65)
PREVENT-AD	71.0	60, 62, 67	13, 15, 18	38.5					1029, 1210, 1353 (26, 50, 75)	186, 260, 335 (26, 50, 75)	36, 46, 58 (26, 50, 75)
PharmaCog	57.1	64, 70, 74	7, 10, 13	46.2	25, 26, 28	0.5, 0.5, 0.5		5459, 6695, 7779	465, 624, 900	253, 377, 595	44, 59, 77
ROSMAP	72.8	73, 79, 84	14, 16, 18	25.1	27, 29, 30
VASCULAR	60.4	59, 64, 70	14, 16, 18			0.0, 0.0, 0.5		6758, 7399, 7949 (17, 41, 72)
VITA	59.2	75, 76, 76	9, 11, 11	20.9	27, 28, 29	0.0, 0.0, 0.0		6189, 6577, 7061 (27, 46, 78)
WMH-AD	57.8	69, 75, 80	8, 8, 8	44.9	14, 22, 25	0.5, 0.5, 1.0		4859, 5784, 6874 (0, 11, 32)

Column	Description
Cohort	Investigated Cohorts
Female %	Proportion of female study participants
Age	25, 50 and 75% quantile of participant age at baseline
Education	25, 50 and 75% quantile of years of education completed by participants age at baseline
APOE e4 %	Proportion of participants with at least one APOE e4 allele
MMSE	25, 50 and 75% quantile of participants Mini Mental State Examination (MMSE) scores at baseline
CDR	25, 50 and 75% quantile of participants Clinical Dementia Rating scale scores at baseline
CDRSB	25, 50 and 75% quantile of participants Clinical Dementia Rating scale sum of boxes scores at baseline
Hippocampus	25, 50 and 75% quantile of participants hippocampus volume at baseline. The quantiles under the ECDF estimated on the respective studies control population are given in parentheses. Some volumes were provided as normalized values. NACC values are given as proportion of “abnormal observations”.
A-beta	25, 50 and 75% quantile of participants CSF amyloid beta at baseline. The quantiles under the ECDF estimated on the respective studies control population are given in parentheses. NACC values are given as proportion of “abnormal observations”.
tTau	25, 50 and 75% quantile of participants CSF total Tau at baseline. The quantiles under the ECDF estimated on the respective studies control population are given in parentheses. NACC values are given as proportion of “abnormal observations”.
pTau	25, 50 and 75% quantile of participants CSF phosphorylated Tau at baseline. The quantiles under the ECDF estimated on the respective studies control population are given in parentheses. NACC values are given as proportion of “abnormal observations”.